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One Step Closer: Scientists Eliminate HIV In Mice

USA Today Jul 13, 2019
This article is deemed a must-read by one or more of our expert collaborators.
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Giving Compass’ Take:

· With the help of gene-editing technology and a slow-release antiviral drug, scientist from Temple University and the University of Nebraska Medical Center have been able to eliminate HIV in mice. 

· What does this news mean about developing a cure for humans? In what ways can donors support more research into developing a cure for HIV?

· Check out this article about the second case of HIV being cured.


Researchers say they’ve successfully eliminated HIV from the DNA of infected mice for the first time, bringing them one step closer to curing the virus in humans.

Scientists from Temple University and the University of Nebraska Medical Center were able to eliminate the virus using a combination of gene-editing technology and a slow-release antiviral drug, according to a study published Tuesday in Nature Communications.

“The possibility exists that HIV can be cured,” Howard Gendelman, chairman of UNMC’s pharmacology and experimental neuroscience department and study author. “It’s going to take a little bit of time but to have the proof of concept gets us all excited.”

Nearly 37 million people are living with HIV, according to UNAIDS, which if left untreated can develop into AIDS. Current HIV treatment involves daily, lifelong antiretroviral therapy (ART) which suppresses the virus’ ability to replicate, but doesn’t eliminate the virus from the body.

Read the full article about progress with HIV by N’dea Yancey-Bragg at USA Today.

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Public Health is a complex topic, and others found these selections from the Impact Giving archive from Giving Compass to be good resources.

  • This article is deemed a must-read by one or more of our expert collaborators.
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    Catalytic Philanthropy for Public Health

    Giving Compass' Take: • Mark R. Kramer explains how philanthropy can make an impact on public health through catalytic grants, using the example of Siebel Systems Inc. founder Thomas Siebel. • How might other philanthropists follow this model? Can we address issues relating to social determinants of health through such grants? • Find out how Atlantic Philanthropies catalyzed investment capital for lasting impact on healthcare. Despite spending vast amounts of money and helping to create the world’s largest nonprofit sector, philanthropists have fallen far short of solving America’s most pressing problems. What the nation needs is “catalytic philanthropy” — a new approach that is already being practiced by some of the most innovative donors. Thomas Siebel does philanthropy differently from other donors. As the founder of the software company Siebel Systems Inc., he is one of a handful of philanthropists who have the resources to devote substantial time and money to charity. His approach and the results he has achieved, however, dramatically distinguish him from most of his peers. In 2005, while spending time on his Montana ranch, Siebel became concerned about the rampant local use of methamphetamine, or “meth.” Meth is a highly addictive and physically destructive drug, and it is a particularly acute problem in rural America. In 2005, Montana had the fifth worst level of meth abuse among all U.S. states. Half of its inmates were imprisoned for meth-related crimes. The direct cost to the state was estimated at nearly $300 million per year, and the cost in human lives and suffering was far greater. Rather than writing a check to a local nonprofit, Siebel took the time to find out why people become addicted to meth. After learning that first-time users were typically teenagers who were unaware of meth’s risks, Siebel created the Meth Project to change teenage perceptions about the drug. He brought together experts and hired a major San Francisco advertising agency to develop a hard-hitting campaign that would reach 80 percent of Montana teens with at least three ads every week. Read the full article about catalytic philanthropy by Mark R. Kramer at Stanford Social Innovation Review.


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